Widespread perturbation of ETS factor binding sites in cancer

Abstract excerpt

Although >90% of somatic mutations reside in non-coding regions, few have been reported as cancer drivers. To predict driver non-coding variants (NCVs), we present a novel transcription factor (TF)-aware burden test (TFA-BT) based on a model of coherent TF function in promoters. We applied our TFA-BT to NCVs from the Pan-Cancer Analysis of Whole Genomes cohort and predicted 2,555 driver NCVs in the promoters of 81...

Topics

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• Binding Sites
• Gene Expression
• Gene Expression Regulation
• Genome, Human
• Mutation
• Neoplasms
• Polymorphism, Single Nucleotide
• Transcription Factors

Identifiers and source

Literature Corpus work

e368bfeb-7023-5cb5-a3fa-f7b3ce5e56b8

DOI

10.1101/2022.08.10.503516