Article
CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.
Cell reports - 22 May 2014
Kemp Christopher J, Moore James M, Moser Russell, Bernard Brady, Teater Matt, Smith Leslie E, Rabaia Natalia A, Gurley Kay E, Guinney Justin, Busch Stephanie E, Shaknovich Rita, Lobanenkov Victor V, Liggitt Denny, Shmulevich Ilya, Melnick Ari, Filippova Galina N
Abstract excerpt
Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. CTCF, a DNA-binding protein that regulates higher-order chromatin organization, is frequently altered by hemizygous deletion or mutation in human cancer. To date, a causal role for CTCF in cancer has not been established. Here, we show that...
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