Article

Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationships

2021-01-08

Abstract excerpt

<h4>Background</h4> Human cancers commonly contain mutations in transcription factors that lead to aberrant DNA binding or altered effector function at target sites. One such factor significantly mutated in cancer is the evolutionarily-conserved CCCTC-binding factor (CTCF), which has fundamental roles in maintaining chromatin architecture and transcriptional regulation. Numerous cancer genome sequencing and funct...

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Literature Corpus work: e796b655-b22b-5c25-8c56-ae2c61dccc8b
DOI: 10.1101/2021.01.08.425848

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