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The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome Organization

2026-08-05

Abstract excerpt

Disruption of three-dimensional genome architecture is a major driver of cancer initiation and progression, frequently arising from genetic and epigenetic alterations at CTCF- and cohesin-bound chromatin anchors. These same chromatin loop anchors can also be occupied by the germ cell-specific CTCF paralog CTCFL (BORIS), which is aberrantly activated in multiple malignancies. Here, we show that in ovarian cancer ce...

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Identifiers and source

Literature Corpus work
9c5ed0d7-87be-5cc8-aea1-2041a72a7bbd
DOI
10.64898/2026.08.04.742596
Open publication

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The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome OrganizationDOI 10.64898/2026.08.04.742596
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