Dynamic 3D chromosomal landscapes in acute leukemia

Abstract excerpt

<h4>ABSTRACT</h4> Three-dimensional (3D) chromatin architectural changes can alter the integrity of topologically associated domains (TADs) and rewire specific enhancer-promoter interactions impacting gene expression. Recently, such alterations have been implicated in human disease, highlighting the need for a deeper understanding of their role. Here, we investigate the reorganization of chromatin architecture in...

Topics

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• Leukemia
• Mutation
• Acute Disease
• Acute Myeloid Leukemia Research
• CCCTC-Binding Factor
• Chromatin
• Gene Expression Regulation, Neoplastic
• Genomics and Chromatin Dynamics

Identifiers and source

Literature Corpus work

e8e34cdc-a4a0-5b45-ad7b-95c481761cc7

DOI

10.1101/724427