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Article

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.

Clinical epigenetics - 5 Jun 2020

Damaschke Nathan A, Gawdzik Joseph, Avilla Mele, Yang Bing, Svaren John, Roopra Avtar, Luo Jian-Hua, Yu Yan P, Keles Sunduz, Jarrard David F

Abstract excerpt

BACKGROUND: The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide DNA methylation sites in human cancer remains undefined. RESULTS: Here, we demonstrate that prostate and breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32503656
DOI: 10.1186/s13148-020-00869-7
PMCID: PMC7275597

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