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Article

AML displays increased CTCF occupancy associated with aberrant gene expression and transcription factor binding

31 Mar 2020

Abstract excerpt

CCTC-binding factor (CTCF) is a key regulator of gene expression through organization of the chromatin structure. Still, it is unclear how CTCF binding is perturbed in leukemia or in cancer in general. We studied CTCF binding by chromatin immunoprecipitation sequencing in cells from patients with acute myeloid leukemia (AML) and in normal bone marrow (NBM) in the context of gene expression, DNA methylation, and...

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Identifiers

PMID: 32232485
DOI: 10.1182/blood.2019002326

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