Article

H3K27 and H3K9 Methylation Mask Potential CTCF Binding Sites to Maintain 3D Genome Integrity

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> The three-dimensional (3D) genome structure is essential for gene regulation and various genomic functions. CTCF plays a key role in organizing Topologically Associated Domains (TADs) and promoter-enhancer loops, contributing to proper cell differentiation and development. Although CTCF binds the genome with high sequence specificity, its binding sites are dynamically regulated during developmen...

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Literature Corpus work: 382ce276-ea1f-544e-a371-f090eaae6054
DOI: 10.1101/2025.04.02.646724

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