Article

The pathological and genomic impact of CTCF depletion in mammalian model systems

2018-01-01

Abstract excerpt

CCCTC-binding factor (CTCF) binds DNA, thereby helping to partition the mammalian genome into discrete structural and regulatory domains. In doing so, it insulates chromatin and fine-tunes gene activation, repression, and silencing. Complete removal of CTCF from mammalian cells causes catastrophic genomic dysregulation, most likely due to widespread collapse of 3D chromatin looping within the nucleus. In contrast,...

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Literature Corpus work: b99e6da3-8a1f-55f5-b3eb-489d48302650
DOI: 10.17863/cam.31776

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