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Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial Fragmentation

2026-03-25

Abstract excerpt

Stress granules (SGs) are dynamic RNA–RBP condensates that form during stress and inflammation, yet how they modulate inflammatory signalling remains unclear. We uncover a rapid, protective SG-mediated mechanism that preserves mitochondrial integrity. During stress and translation inhibition, mitochondrial fragmentation releases double-stranded RNA (dsRNA), which activates PKR and its downstream effector DRP1, gen...

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Identifiers and source

Literature Corpus work
b580f93d-5e91-5642-9e53-31cee597dba4
DOI
10.64898/2026.03.23.713569
Open publication

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Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial FragmentationDOI 10.64898/2026.03.23.713569
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