Article
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Nature - 1 Oct 2023
Victorelli Stella, Salmonowicz Hanna, Chapman James, Martini Helene, Vizioli Maria Grazia, Riley Joel S, Cloix Catherine, Hall-Younger Ella, Machado Espindola-Netto Jair, Jurk Diana, Lagnado Anthony B, Sales Gomez Lilian, Farr Joshua N, Saul Dominik, Reed Rebecca, Kelly George, Eppard Madeline, Greaves Laura C, Dou Zhixun, Pirius Nicholas, Szczepanowska Karolina, Porritt Rebecca A, Huang Huijie, Huang Timothy Y, Mann Derek A, Masuda Claudio Akio, Khosla Sundeep, Dai Haiming, Kaufmann Scott H, Zacharioudakis Emmanouil, Gavathiotis Evripidis, LeBrasseur Nathan K, Lei Xue, Sainz Alva G, Korolchuk Viktor I, Adams Peter D, Shadel Gerald S, Tait Stephen W G, Passos João F
Abstract excerpt
Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane...
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