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Article

Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial Fragmentation

2026-07-31

Abstract excerpt

<title>Abstract</title> <p>Stress granules (SGs) are dynamic RNA-RBP condensates that form during stress and inflammation, yet how they modulate inflammatory signalling remains unclear. We uncover a rapid, protective SG-mediated mechanism that preserves mitochondrial integrity. During stress and translation inhibition, mitochondrial fragmentation releases double-stranded RNA (dsRNA), which activates PKR and its d...

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Literature Corpus work
a28942c7-7078-532e-ab80-25e1a18881d9
DOI
10.21203/rs.3.rs-10247851/v1
Open publication

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Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial FragmentationDOI 10.21203/rs.3.rs-10247851/v1
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