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Dr. Jekyll and Mr. Hyde? Physiology and Pathology of Neuronal Stress Granules

25 Feb 2021

Abstract excerpt

Stress granules (SGs) are membraneless cytosolic granules containing dense aggregations of RNA-binding proteins and RNAs. They appear in the cytosol under stress conditions and inhibit the initiation of mRNA translation. SGs are dynamically assembled under stressful conditions and rapidly disassembled after stress removal. They are heterogeneous in their RNA and protein content and are cell type- and...

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PMID: 33718353
DOI: 10.3389/fcell.2021.609698

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