Article

Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

2023-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation is an age-related factor that underlies numerous human disorders. A key driver of inflammation is the release of mitochondrial DNA (mtDNA), which binds and activates cytosolic sensors. This induces transcriptional responses and, ultimately, pyroptotic cell death. The main challenge has been to understand how mtDNA can cross the two mitochondrial membranes to access the cytosol. Thro...

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Literature Corpus work: df48cc98-eecb-512e-aca2-affceb5ee46b
DOI: 10.1101/2023.09.11.557213

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