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Mitochondrial Quality Control and Restraining Innate Immunity

6 Oct 2020

Abstract excerpt

Maintaining mitochondrial health is essential for the survival and function of eukaryotic organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore mitochondrial network homeostasis, remove damaged or toxic proteins, and eliminate damaged organelles via selective autophagy of mitochondria, a process termed mitophagy. Failure of these quality control pathways is implicated in the...

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PMID: 33021820
DOI: 10.1146/annurev-cellbio-021820-101354

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