Stress granule–mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular aging

Abstract excerpt

Male infertility remains a major unmet medical challenge, with poorly defined molecular mechanisms and no effective therapies. Here, we identify a stress granule–mediated necroptotic pathway as a key driver of non-obstructive azoospermia, a severe form of male infertility marked by the loss of spermatogenesis. Environmental or physiological stress activates eIF2α kinases, inducing stress granule formation and the...

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