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Article

Endogenous pathology in tauopathy mice progresses via brain networks

2023-05-24

Abstract excerpt

Neurodegenerative tauopathies are hypothesized to propagate via brain networks. This is uncertain because we have lacked precise network resolution of pathology. We therefore developed whole-brain staining methods with anti-p-tau nanobodies and imaged in 3D PS19 tauopathy mice, which have pan-neuronal expression of full-length human tau containing the P301S mutation. We analyzed patterns of p-tau deposition across...

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Literature Corpus work
3e624fb6-7512-5b5c-99f6-6596af43b18b
DOI
10.1101/2023.05.23.541792
Open publication

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Endogenous pathology in tauopathy mice progresses via brain networksDOI 10.1101/2023.05.23.541792
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