Article

Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer’s Disease

2026-02-09

Abstract excerpt

Alzheimer’s Disease (AD) is distinguished by the presence of two key pathological features: amyloid plaques, accumulations of proteolytic products of Amyloid Precursor Protein, and neurofibrillary tangles (NFTs), intracellular aggregations of microtubule-associated protein tau. NFTs first appear in particular entorhinal cortex (EC) neurons (called pre-alpha neurons) in asymptomatic patients, then continue to sprea...

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Literature Corpus work: 873196c0-8db6-5410-a60c-551de7b4e6b4
DOI: 10.64898/2026.02.05.703778

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