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Single <i>MAPT</i> knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community

2024-11-15

Abstract excerpt

We recently reported development of human MAPT knock-in mice that carry single or double pathogenic mutations of frontotemporal dementia. However, it takes more than 14 months for the line with the most aggressive phenotypes to exhibit tau pathology without forming high-order tau oligomers, along with concomitant abnormal behavior. We thus generated MAPT knock-in mice carrying triple mutations, among which the...

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Literature Corpus work
c4e9d9b6-7cf3-5ef8-9676-d776c29562ee
DOI
10.1101/2024.11.15.623736
Open publication

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Single <i>MAPT</i> knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research communityDOI 10.1101/2024.11.15.623736
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