Article

Spreading of Tau Protein Does Not Depend on Aggregation Propensity

2021-03-31

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The stereotypical progression of Tau pathology during Alzheimer disease has been attributed to trans-neuronal spreading of misfolded Tau proteins, followed by prion-like templated aggregation of Tau. The nature of Tau and the cellular mechanisms of Tau spreading are still under debate. We hypothesized that Tau's propensity for aggregation would correlate with it...

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Literature Corpus work: c743a73a-a165-5e63-a4d2-836385d69e1e
DOI: 10.21203/rs.3.rs-356350/v1

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