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Article

Propagation of tau pathology in a model of early Alzheimer's disease.

Neuron - 23 Feb 2012

de Calignon Alix, Polydoro Manuela, Suárez-Calvet Marc, William Christopher, Adamowicz David H, Kopeikina Kathy J, Pitstick Rose, Sahara Naruhiko, Ashe Karen H, Carlson George A, Spires-Jones Tara L, Hyman Bradley T

Abstract excerpt

Neurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic and association cortices as Alzheimer's disease evolves. However, the mechanism involved in this hierarchical pattern of disease progression is unknown. We describe a transgenic mouse model in which overexpression of human tau P301L is restricted to EC-II. Tau pathology progresses from EC transgene-expressing neurons to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22365544
DOI: 10.1016/j.neuron.2011.11.033
PMCID: PMC3292759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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