Article

Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer’s disease neuropathology

2025-01-01

Abstract excerpt

Neurons located in layer II of the entorhinal cortex (ECII) are the primary site of pathological tau accumulation and neurodegeneration at preclinical stages of Alzheimer’s disease (AD). Exploring the alterations that underlie the early degeneration of these cells is essential to develop therapies that curb the disease before symptom onset. Here we performed cell-type specific profiling of human EC at the onset of...

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Literature Corpus work: 3b8532b9-71e8-58b4-ab21-75d542758dda
DOI: 10.1101/2024.12.31.630881

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