Article

Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

2020-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Tau pathology is a diagnostic feature of Alzheimer’s disease (AD) but is also a prominent feature of Parkinson’s disease (PD), including genetic forms of PD with mutations in leucine-rich repeat kinase 2 ( LRRK2 ). In both diseases, tau pathology is progressive and correlates with cognitive decline. Neuropathological staging studies in humans and mouse models have suggested that tau spreads thr...

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Literature Corpus work: 2417a7dd-080f-5bf8-aa72-be1687992c64
DOI: 10.1101/2020.10.13.337857

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