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Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment

2025-12-31

Abstract excerpt

<h4>ABSTRACT</h4> Tau pathology in the entorhinal cortex (EC) is associated with spatial memory decline in aging and early-stage Alzheimer’s disease, but its impact on EC computations during learning is not well understood. We performed longitudinal two-photon calcium imaging of layer 2 excitatory neurons in the medial EC (MEC) of PS19 tauopathy mice over 10 days of an operant spatial learning task. Male PS19 mic...

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Literature Corpus work
34a77fba-8fa2-5bb7-af64-741f65235b92
DOI
10.64898/2025.12.30.696887
Open publication

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Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentDOI 10.64898/2025.12.30.696887
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