Article

Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D Hydrogels

2025-04-12

Abstract excerpt

The mechanical properties of the extracellular matrix (ECM), particularly stiffness, regulate endothelial progenitor responses during vascular development, yet their behavior in physiologically compliant matrices (<1 kPa) remains underexplored. Using norbornene-modified hyaluronic acid (NorHA) hydrogels with tunable stiffness (190–884 Pa), we investigated how hydrogel stiffness influences cell morphology, endothel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5510fbc-de43-5ee0-a834-b370439b5db1
DOI: 10.1101/2025.04.11.648340

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D HydrogelsDOI 10.1101/2025.04.11.648340Read

Matrix stiffness-induced transcriptome alterations and regulatory mechanisms revealed by RNA-seq in Endothelial cellsSemantic proximity Read

The Effect of Mechanical Stimuli on the Phenotypic Plasticity of Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells in a 3D HydrogelSemantic proximity Read

Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions.Semantic proximity Read

The extracellular matrix mechanics in the vasculature.Semantic proximity Read

Synergistic effects of matrix nanotopography and stiffness on vascular smooth muscle cell function.Semantic proximity Read

Engineering a Matrix-Preserving Vascular dECM Platform with Tunable Stiffness for <i>In Vitro</i> Vascular RemodelingSemantic proximity Read

Compliant substratum guides endothelial commitment from human pluripotent stem cellsSemantic proximity Read

Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics.Semantic proximity Read

Matrix stiffness regulates the tight junction phenotypes and local barrier properties in tricellular regions in an iPSC-derived BBB model.Semantic proximity Read

Cardiac myocytes respond differentially and synergistically to matrix stiffness and topographySemantic proximity Read

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read

Effects of substrate stiffness on the biological behavior of human umbilical vein endothelial cellsSemantic proximity Read