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Article

Matrix stiffness regulates the tight junction phenotypes and local barrier properties in tricellular regions in an iPSC-derived BBB model.

Acta biomaterialia - 1 Sept 2023

Yan Li, Dwiggins Cole W, Moriarty Rebecca A, Jung Jae W, Gupta Udit, Brandon Ken D, Stroka Kimberly M

Abstract excerpt

The blood-brain barrier (BBB) can respond to various mechanical cues such as shear stress and substrate stiffness. In the human brain, the compromised barrier function of the BBB is closely associated with a series of neurological disorders that are often also accompanied by the alteration of brain stiffness. In many types of peripheral vasculature, higher matrix stiffness decreases barrier function of...

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Identifiers

PMID: 37302732
DOI: 10.1016/j.actbio.2023.06.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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