Article

Cardiac myocytes respond differentially and synergistically to matrix stiffness and topography

2019-06-27

Abstract excerpt

During cardiac disease progression, myocytes undergo molecular, functional and structural changes, including increases in cell size and shape, decreased myocyte alignment and contractility. The heart often increases extracellular matrix production and stiffness, which affect myocytes. The order and hierarchy of these events remain unclear as available in vitro cell culture systems do not adequately model both phy...

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Literature Corpus work: 439a382b-301d-5b2f-88f9-06d6d56e3c69
DOI: 10.1101/682930

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