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Article

Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2022

Schnellmann Rahel, Ntekoumes Dimitris, Choudhury Mohammad Ikbal, Sun Sean, Wei Zhao, Gerecht Sharon

Abstract excerpt

Aging is a major risk factor in microvascular dysfunction and disease development, but the underlying mechanism remains largely unknown. As a result, age-mediated changes in the mechanical properties of tissue collagen have gained interest as drivers of endothelial cell (EC) dysfunction. 3D culture models that mimic age-mediated changes in the microvasculature can facilitate mechanistic understanding. A fibrillar...

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PMID: 35657074
DOI: 10.1002/advs.202201483
PMCID: PMC9353494

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