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Article

Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics.

Biomaterials science - 30 Sept 2020

Kothapalli Chandrasekhar, Mahajan Gautam, Farrell Kurt

Abstract excerpt

While the mechanotransduction-induced fate of adult neural stem/progenitor cells (NPCs) is relatively known, how substrate stiffness regulates the temporal evolution of the biomechanics and phenotype of developmentally relevant human fetal NPCs (hNPCs) and their mechanosensing pathways remain unknown. Here, we primed hNPCs on tissue-culture plastic (TCPS) for 3 days in non-differentiating medium before...

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Identifiers

PMID: 32996962
DOI: 10.1039/d0bm01349h
PMCID: PMC8500671

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