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Article

Synergistic effects of matrix nanotopography and stiffness on vascular smooth muscle cell function.

Tissue engineering. Part A - 1 Aug 2014

Chaterji Somali, Kim Peter, Choe Seung H, Tsui Jonathan H, Lam Christoffer H, Ho Derek S, Baker Aaron B, Kim Deok-Ho

Abstract excerpt

Vascular smooth muscle cells (vSMCs) retain the ability to undergo modulation in their phenotypic continuum, ranging from a mature contractile state to a proliferative, secretory state. vSMC differentiation is modulated by a complex array of microenvironmental cues, which include the biochemical milieu of the cells and the architecture and stiffness of the extracellular matrix. In this study, we demonstrate that...

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Identifiers

PMID: 24694244
DOI: 10.1089/ten.tea.2013.0455
PMCID: PMC4137359

Genes

ROCK1
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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