Article

Single residue changes to the histone core catalyze neofunctionalization and impose fitness trade-offs

2024-05-10

Abstract excerpt

Histones are among the most conserved proteins in the eukaryotic genome, and their function is thought to be largely invariant across species. Here, we tested this assumption, examining over a billion years of the essential histone H2A.Z’s evolution in a single synthetic host. We identify single residue substitutions within the H2A.Z core domain that led to its neofunctionalization. Such H2A.Z neomorphs are distin...

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Literature Corpus work: b53fc123-d22c-5cb3-9e1e-37a442ed4924
DOI: 10.1101/2024.05.10.593535

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