Article

Hypermutability of ultraconserved histone genes and its contribution to human disease

2026-06-14

Abstract excerpt

Histone genes are among the most evolutionarily conserved sequences in eukaryotes, reflecting their essential role in nucleosome architecture. Intriguingly, our analysis reveals unexpectedly high germline mutation rates in replication-dependent histone genes across vertebrates. We provide multiple lines of evidence suggesting that this hypermutability is largely driven by off-target mutagenic effects of AID/APOBEC...

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Literature Corpus work: 6b500ac9-7167-5e12-8698-b1cf92408a42
DOI: 10.64898/2026.06.11.731563

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