Article
The mechanistic GEMMs of oncogenic histones.
Human molecular genetics - 20 Oct 2020
Lindroth Anders M, Park Yoon Jung, Matía Verónica, Squatrito Massimo
Abstract excerpt
The last decade's progress unraveling the mutational landscape of all age groups of cancer has uncovered mutations in histones as vital contributors of tumorigenesis. Here we review three new aspects of oncogenic histones: first, the identification of additional histone mutations potentially contributing to cancer formation; second, tumors expressing histone mutations to study the crosstalk of post-translational...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.