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Article

What makes a histone variant a variant: Changing H2A to become H2A.Z.

PLoS genetics - 1 Dec 2021

Brewis Hilary T, Wang Alice Y, Gaub Aline, Lau Justine J, Stirling Peter C, Kobor Michael S

Abstract excerpt

Chromatin structure and underlying DNA accessibility is modulated by the incorporation of histone variants. H2A.Z, a variant of the H2A core histone family, plays a distinct and essential role in a diverse set of biological functions including gene regulation and maintenance of heterochromatin-euchromatin boundaries. Although it is currently unclear how the replacement of H2A with H2A.Z can regulate gene...

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Identifiers

PMID: 34871303
DOI: 10.1371/journal.pgen.1009950
PMCID: PMC8675926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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