Article

Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis

2024-12-23

Abstract excerpt

Histones are key epigenetic factors for regulating the accessibility and compaction of eukaryotic genomes, affecting the replication, repair, and expression of DNA. Recent studies have demonstrated that histone missense mutations can perturb normal histone function, promoting the development of phenotypically distinguishable cancers. However, most histone mutations observed in cancer patients remain enigmatic in t...

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Literature Corpus work: 9328e1a9-18c6-512c-a09f-4ee4c55329dc
DOI: 10.1101/2024.12.21.629746

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