Article

STAT1 sets microglial neutral-lipid content independently of lipid-handling transcriptional programs

2026-08-20

Abstract excerpt

Inflammatory activation and lipid remodeling are linked features of microglial states, but how inflammatory transcription factors shape microglial lipid handling is unclear. Here we show that STAT1 sets neutral-lipid content in microglia through a route not predicted by lipid-handling transcription. Acute STAT1 depletion in primary microglia lowered neutral-lipid content while lipid-uptake and lipid-storage progra...

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Literature Corpus work: b4f794f4-4797-5793-abd4-6791f32379de
DOI: 10.64898/2026.08.15.745002

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