Article

Hierarchical determinants of the oxidation-induced mutational landscape in human cells

2024-04-11

Abstract excerpt

8-oxoguanine (8-oxoG) is a common oxidative DNA lesion, which causes G>T substitutions that compose COSMIC single base substitution signature 18 (SBS18) in human cancers. Determinants of local and regional differences in 8-oxoG-induced mutability are currently unknown. To uncover factors influencing the topology of 8-oxoG-induced mutations, we assessed spontaneous and KBrO 3 -induced 8-oxoG mutagenesis in human c...

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Literature Corpus work: 371970bd-107b-5a5d-800f-76b8ef6790ad
DOI: 10.1101/2024.04.08.588428

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