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Article

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.

Nucleic acids research - 1 Aug 2011

Yuan Bifeng, Wang Jianshuang, Cao Huachuan, Sun Ruobai, Wang Yinsheng

Abstract excerpt

Human cells are constantly exposed to environmental and endogenous agents which can induce damage to DNA. Understanding the implications of these DNA modifications in the etiology of human diseases requires the examination about how these DNA lesions block DNA replication and induce mutations in cells. All previously reported shuttle vector-based methods for investigating the cytotoxic and mutagenic properties of...

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Identifiers

PMID: 21470959
DOI: 10.1093/nar/gkr159
PMCID: PMC3152323

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