Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.

International journal of molecular sciences - 18 Jun 2023

Lirussi Lisa, Nilsen Hilde Loge

Abstract excerpt

Chemically modified nucleic acid bases are sources of genomic instability and mutations but may also regulate gene expression as epigenetic or epitranscriptomic modifications. Depending on the cellular context, they can have vastly diverse impacts on cells, from mutagenesis or cytotoxicity to changing cell fate by regulating chromatin organisation and gene expression. Identical chemical modifications exerting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Methylation
Share to DNA Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 37373453
DOI: 10.3390/ijms241210307
PMCID: PMC10299163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Glycosylases Define the Outcome of Endogenous Base Modifications.PMID 37373453Read ↗

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1.Semantic proximity Read ↗

Error-free versus mutagenic processing of genomic uracil—Relevance to cancerSemantic proximity Read ↗

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracilSemantic proximity Read ↗

Action mechanism of human SMUG1 uracil-DNA glycosylase.Semantic proximity Read ↗

[GO System, a DNA Repair Pathway to Cope with Oxidative Damage].Semantic proximity Read ↗

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.Semantic proximity Read ↗

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporationSemantic proximity Read ↗

Dissecting mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damageSemantic proximity Read ↗

Mapping the sequence logic of DNA repair enzyme binding reveals mechanistic principles and evolutionary linksSemantic proximity Read ↗

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairingSemantic proximity Read ↗

Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistanceSemantic proximity Read ↗

The search for single DNA damage among millions of base pairs: DNA glycosylases trapped at work.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.