Article

Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cells

2024-07-23

Abstract excerpt

DNA modifications drive aging, neurodegeneration, carcinogenesis, and chemotherapy drug action. To understand the functional genomic roles of DNA modifications, it is critical to accurately map their diverse chemical forms with single-nucleotide precision in complex genomes, but it remains challenging. Click-code-seq is a click-chemistry-aided single-nucleotide-resolution strategy for guanine-oxidation mapping, us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfdc08e7-3702-5bfb-b07b-ecae35465ebc
DOI: 10.1101/2024.07.21.604463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cellsDOI 10.1101/2024.07.21.604463Read

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesisSemantic proximity Read

Optimized chemical labeling method for isolation of 8-oxoG-modified RNA, ChLoRox-Seq, identifies mRNAs enriched in oxidation and transcriptome-wide distribution biases of oxidation events post environmental stressSemantic proximity Read

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and mispairingSemantic proximity Read

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.Semantic proximity Read

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.Semantic proximity Read

FFPE DNA shows two major error profiles derived from deamination of cytosine and methylcytosine that can be mitigated using distinct repair strategiesSemantic proximity Read

DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification.Semantic proximity Read

Methyl-CODEC enables simultaneous methylation and duplex sequencingSemantic proximity Read

iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis.Semantic proximity Read

Compound-specific DNA adduct profiling with nanopore sequencing and IonStatsSemantic proximity Read

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic MutationsSemantic proximity Read

Methods and applications of genome-wide profiling of DNA damage and rare mutations.Semantic proximity Read