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Article

Contributing factors to the oxidation-induced mutational landscape in human cells.

Nature communications - 23 Dec 2024

Cordero Cameron, Mehta Kavi P M, Weaver Tyler M, Ling Justin A, Freudenthal Bret D, Cortez David, Roberts Steven A

Abstract excerpt

8-oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G > T substitutions. Determinants of local and regional differences in 8-oxoG-induced mutability across genomes are currently unknown. Here, we show DNA oxidation induces G > T substitutions and insertion/deletion (INDEL) mutations in human cells and cancers. Potassium bromate (KBrO3)-induced 8-oxoGs occur with similar sequence preferences as...

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Chromatin
Cryoelectron Microscopy
DNA Damage
DNA Glycosylases
Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

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PMID: 39715760
DOI: 10.1038/s41467-024-55497-z
PMCID: PMC11666792

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