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Error-free versus mutagenic processing of genomic uracil—Relevance to cancer

18 Apr 2014

Abstract excerpt

Genomic uracil is normally processed essentially error-free by base excision repair (BER), with mismatch repair (MMR) as an apparent backup for U:G mismatches. Nuclear uracil-DNA glycosylase UNG2 is the major enzyme initiating BER of uracil of U:A pairs as well as U:G mismatches. Deficiency in UNG2 results in several-fold increases in genomic uracil in mammalian cells. Thus, the alternative uracil-removing...

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PMID: 24746924
DOI: 10.1016/j.dnarep.2014.03.028

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