Article

Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

2020-08-19

Abstract excerpt

<h4>Summary</h4> Recent studies demonstrated that the mutational load in human induced pluripotent stem cells (hiPSCs) is largely derived from their parental cells, but it is still unknown whether reprogramming may enrich for individual mutations. 30 hiPSC lines were analyzed by whole exome sequencing. High accuracy amplicon sequencing showed that all analyzed small scale variants pre-existed in their parental ce...

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Literature Corpus work: b466aa5e-5048-5ec5-a72f-738effebcd73
DOI: 10.1101/2020.08.19.257238

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