Article
Reprogramming enriches for somatic cell clones with small-scale mutations in cancer-associated genes.
Molecular therapy : the journal of the American Society of Gene Therapy - 4 Aug 2021
Kosanke Maike, Osetek Katarzyna, Haase Alexandra, Wiehlmann Lutz, Davenport Colin, Schwarzer Adrian, Adams Felix, Kleppa Marc-Jens, Schambach Axel, Merkert Sylvia, Wunderlich Stephanie, Menke Sandra, Dorda Marie, Martin Ulrich
Abstract excerpt
Cellular therapies based on induced pluripotent stem cells (iPSCs) come out of age and an increasing number of clinical trials applying iPSC-based transplants are ongoing or in preparation. Recent studies, however, demonstrated a high number of small-scale mutations in iPSCs. Although the mutational load in iPSCs seems to be largely derived from their parental cells, it is still unknown whether reprogramming may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.