Article
Genomic analysis of hESC pedigrees identifies de novo mutations and enables determination of the timing and origin of mutational events.
Cell reports - 26 Sept 2013
Ben-Yosef Dalit, Boscolo Francesca S, Amir Hadar, Malcov Mira, Amit Ami, Laurent Louise C
Abstract excerpt
Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in human induced pluripotent stem cells (hiPSCs) have shown that deletions and regions of loss of heterozygosity (LOH) tend to arise during reprogramming and early culture, whereas duplications more frequently occur during...
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