Article

Multiomic Profiling of 85 iPSC Lines from Familial Dementia Reveals Cellular Diversity and Regulators of Organoid Development

2026-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Patient-derived induced pluripotent stem cells (iPSCs) are used for disease modeling and therapeutic development, yet their systematic molecular and genetic characterization is uncommon. Here, we performed whole genome sequencing (WGS), bulk/single-cell RNA-sequencing (RNA-seq) and DNA methylation analysis on 85 iPSC lines harboring MAPT mutations and corresponding isogenic controls. Single-cel...

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Literature Corpus work: d690d5ed-9be9-51bd-bb9b-98e07bb11c0c
DOI: 10.64898/2026.04.29.721747

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