Article

Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating Disease

2021-12-27

Abstract excerpt

Biological aging is the strongest factor associated with the clinical phenotype of multiple sclerosis (MS). Relapsing remitting MS (RRMS) typically presents in the third or fourth decade, while the mean age of presentation of progressive MS (pMS) is 45 years old. Here we show that experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of encephalitogenic CD4 + Th17 cells, is more severe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b433e24f-30e3-59b8-8e32-30bcdcc3478b
DOI: 10.1101/2021.12.26.473589

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating DiseaseDOI 10.1101/2021.12.26.473589Read

Biological aging in multiple sclerosisSemantic proximity Read

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenationSemantic proximity Read

Age-associated changes in rat immune system: lessons learned from experimental autoimmune encephalomyelitis.Semantic proximity Read

Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative DiseasesSemantic proximity Read

Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their FailureSemantic proximity Read

Microglial brain region-dependent diversity and selective regional sensitivities to aging.Semantic proximity Read

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MSSemantic proximity Read

Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humansSemantic proximity Read

DJ-1 depletion slows down immunoaging in T-cell compartmentsSemantic proximity Read

Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injurySemantic proximity Read