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Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS

9 May 2024

Abstract excerpt

Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated changes and their contribution to diseases are only poorly understood. The white matter in the aging brain as well as in diseases, such as Multiple sclerosis is characterized by subtle abnormalities in myelin sheaths and paranodes, suggesting that...

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PMID: 38722375
DOI: 10.1007/s00401-024-02733-x

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