Back to search

Article

DJ-1 depletion slows down immunoaging in T-cell compartments

2021-05-22

Abstract excerpt

Decline in immune function during aging increases susceptibility to different aging related diseases. However, the underlying molecular mechanisms, especially the genetic factors contributing to imbalance of naïve/memory T-cell subpopulations, still remain largely elusive. Here we show that loss of DJ-1 encoded by PARK7 /DJ-1, causing early-onset familial Parkinson’s disease (PD), unexpectedly delayed immunoaging...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abc4989d-13b1-5c14-ae29-aec36e21d1a3
DOI
10.1101/2021.05.21.445139
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DJ-1 depletion slows down immunoaging in T-cell compartmentsDOI 10.1101/2021.05.21.445139
Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells.Semantic proximity
Adaptive Immunity and Parkinson's Disease.Semantic proximity
Mechanisms of immunosenescence: lessons from models of accelerated immune agingSemantic proximity
Aging Of Antiviral CD8 <sup>+</sup> Memory T Cells Fosters Increased Survival, Metabolic Adaptations And Lymphoid Tissue HomingSemantic proximity
T cell aging and exhaustion: Mechanisms and clinical implicationsSemantic proximity
Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating DiseaseSemantic proximity
Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart StudySemantic proximity
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus InfectionSemantic proximity
PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic targetSemantic proximity
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasisSemantic proximity
The <i>R1441C-LRRK2</i> mutation induces myeloid immune cell exhaustion in an age- and sex-dependent mannerSemantic proximity
Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalitiesSemantic proximity
Select a neighboring publication to make it the new centre.