Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their Failure

31 Mar 2022

Abstract excerpt

The advent of disease modifying therapies (DMT) in the past two decades has been the cornerstone of successful clinical management of multiple sclerosis (MS). Despite the great strides made in reducing the relapse frequency and occurrence of new signal changes on neuroimaging in patients with relapsing remitting MS (RRMS) by approved DMT, it has been challenging to demonstrate their effectiveness in non-active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Sclerosis Research Studies
Share to Neurogenesis and neuroplasticity mechanisms
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35432156
DOI: 10.3389/fneur.2022.854390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their FailurePMID 35432156Read ↗

Biological aging in multiple sclerosisSemantic proximity Read ↗

Targeting senescence to delay progression of multiple sclerosisSemantic proximity Read ↗

Immunosenescence in multiple sclerosis: the identification of new therapeutic targetsSemantic proximity Read ↗

Smoking Accelerates Immunosenescence in Multiple SclerosisSemantic proximity Read ↗

Characterization of Antigen-Induced CD4+ T-Cell Senescence in Multiple SclerosisSemantic proximity Read ↗

Cellular Senescence in Glial Cells: Implications for Multiple SclerosisSemantic proximity Read ↗

Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing ageSemantic proximity Read ↗

Immunological differences between classical phenothypes of multiple sclerosis.Semantic proximity Read ↗

Recent advances in understanding multiple sclerosisSemantic proximity Read ↗

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological StudySemantic proximity Read ↗

Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating DiseaseSemantic proximity Read ↗

Cellular senescence and failure of myelin repair in multiple sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.